Yes, provided you don't mind discarding any existing backups you can remove the whole folder once you've uninstalled iTunes See Relocate iOS device backups for a method to AppData\Roaming is where programs on your machine store data that is specific to your user account The folder is normally hidden, and lives within your user account home The way it'll work is your uninstall leaves the EXE and registry entry behind so that when a user logs on it's roaming data gets pulled down from the server to local and Active Setup
Windows Appdata Folder Show And Manage Application Data Ionos
